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Fig. 1 · Structure
Cat. No.
A12024
CAS No.
471-95-4
Formula
C26H36O6
Mol. Weight
444.6

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Bufotalin

Cat. No. A12024 CAS 471-95-4
Bufotalin is a less potent Na+/K+-ATPase inhibitor than other bufadienolides. Potent immunosuppressor.

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Biological Activity

Cellular Effect

Cell Line Activity Value Description Reference
A549 IC50 0.9 μM Cytotoxicity against human A549 cells after 24 hrs by MTT assay [PMID: 24050254]
A549 IC50 14 nM Cytotoxicity against human A549 cells after 3 days by MTT assay [PMID: 23706005]
B16-F10 IC50 > 10000 nM Cytotoxicity against mouse B16F10 cells after 3 days by MTT assay [PMID: 23706005]
CT26.WT IC50 > 10000 nM Cytotoxicity against mouse CT26.WT cells after 3 days by MTT assay [PMID: 23706005]
HepG2 IC50 0.5 μM Cytotoxicity against human HepG2 cells after 24 hrs by MTT assay [PMID: 24050254]
HL-60 IC50 < 0.01 μg/mL Cytotoxicity against human HL60 cells after 72 hrs by MTT assay [PMID: 11575946]
Hs 683 IC50 9 nM Cytotoxicity against human Hs683 cells after 3 days by MTT assay [PMID: 23706005]
KB IC50 0.19 μg/mL Cytotoxicity against human KB cells after 72 hrs by MTT assay [PMID: 11575946]
MCF7 IC50 37 nM Cytotoxicity against human MCF7 cells after 3 days by MTT assay [PMID: 23706005]
MH60 IC50 > 25 μg/mL Cytotoxicity against mouse MH60 cells after 72 hrs by MTT assay [PMID: 11575946]
MH60 IC50 > 56.2 μM Growth inhibition of IL-6-independent mouse MH60 cells after 72 hrs by MTT assay [PMID: 15620253]
MH60 IC50 > 56.2 μM Growth inhibition of IL6-dependent mouse MH60 cells after 72 hrs by MTT assay in presence of human recombinant IL6 [PMID: 15620253]
PC-3 IC50 34 nM Cytotoxicity against human PC3 cells after 3 days by MTT assay [PMID: 23706005]
SK-MEL-28 IC50 65 nM Cytotoxicity against human SK-MEL-28 cells after 3 days by MTT assay [PMID: 23706005]
U-373MG ATCC IC50 74 nM Cytotoxicity against human U373 cells after 3 days by MTT assay [PMID: 23706005]

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Specifications

Manufacturer Adooq Bioscience
Actions Inhibitor
CAS Number 471-95-4
Formula C26H36O6
Molecular Weight 444.6
SMILES
C[C@@]12[C@](C3=COC(C=C3)=O)([H])[C@H](C[C@@]1([C@@]4([H])[C@]([C@@]5([C@](C[C@H](CC5)O)([H])CC4)C)([H])CC2)O)OC(C)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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