Bufothionine is a natural alkaloid with anticancer properties, isolated from Cinobufacini. It induces apoptosis through a mitochondria-mediated pathway and effectively reduces serum IL-6 levels while suppressing the expression of p-Stat3tyr705, p-Stat3ser727, and Jak2. Bufothionine also promotes autophagy by upregulating key autophagy-related proteins Atg5, Atg7, and LC3Ⅱ, while inhibiting PIM3 expression. Its efficacy in preclinical models demonstrates significant anti-cancer activity against gastric cancer and highlights its potential role in therapeutic applications.
Bufothionine is a natural alkaloid with anticancer properties, isolated from Cinobufacini. It induces apoptosis through a mitochondria-mediated pathway and effectively reduces serum IL-6 levels while suppressing the expression of p-Stat3tyr705, p-Stat3ser727, and Jak2. Bufothionine also promotes autophagy by upregulating key autophagy-related proteins Atg5, Atg7, and LC3Ⅱ, while inhibiting PIM3 expression. Its efficacy in preclinical models demonstrates significant anti-cancer activity against gastric cancer and highlights its potential role in therapeutic applications.
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