Fig. 1 · Structure

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Bumetanide sodium

NKCC1 Inhibitor

Bumetanide sodium is a potent inhibitor of the Na+-K+-Cl- cotransporter (NKCC), specifically targeting NKCC1 with an IC50 of 0.68 μM, and NKCC2 with an IC50 of 4.0 μM. As a loop diuretic, this compound plays a crucial role in studies related to electrolyte balance and fluid regulation. It is utilized in research applications concerning renal function, hypertension, and heart failure.

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Specifications

Manufacturer Adooq Bioscience
Actions Inhibitor
CAS Number 28434-74-4
Applications NKCC1 Inhibitor
Formula C17H19N2NaO5S
Molecular Weight 386.40
Synonyms Ro 10-6338 sodium; PF 1593 sodium
SMILES
O=C(O[Na])C1=CC(NCCCC)=C(OC2=CC=CC=C2)C(S(=O)(N)=O)=C1

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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