Fig. 1 · Structure
Documents & Downloads
C2 L-threo Ceramide (d18:1/2:0)
Sphingolipid
C2 L-threo Ceramide (d18:1/2:0) is a bioactive sphingolipid that acts as a cell-permeable analog of natural ceramides. It is known to stimulate cholesterol efflux in CHO cells expressing the human ABCA1 receptor at a concentration of 10 μM, although the effect is 50% less than that of C2 ceramide. Additionally, it inhibits IL-4 production by 17% in EL4 T cells when stimulated with phorbol 12-myristate 13-acetate at the same concentration. C2 L-threo Ceramide also induces cell cycle arrest in the G0/G1 phase and significantly increases sphingosine accumulation, demonstrating growth inhibition in HL-60 leukemia cells.
In Stock
Free Aliquoting for Your Order
Tell us your preferred amount per vial. We’ll confirm the options.
Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 143615-69-4 |
| Applications | Sphingolipid |
| Formula | C20H39NO3 |
| Molecular Weight | 341.53 |
| Synonyms | L-threo Cer(d18:1/2:0); L-threo Ceramide (d18:1/2:0); N-acetyl-L-threo-Sphingosine |
| SMILES | CC(N[C@H]([C@H](/C=C/CCCCCCCCCCCCC)O)CO)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.