Sphingolipids

Cat. No.

A25880

CAS No.

59247-13-1

Ganglioside GT1b (bovine) ammonium

Ganglioside GT1b (bovine) is a member of the ganglioside family, primarily targeting neuronal cells. It plays a crucial role in protecting against spinal synapse elimination following nerve injury and promotes hyaluronic acid synthesis along with the phosphorylation of Akt/mTOR in orbital fibroblasts. Ganglioside GT1b also enhances porcine oocyte maturation and activates EGFR and ERK1/2 signaling pathways. Its diverse applications in research span cancer, infectious diseases, immunology, endocrinology, and neurological disorders, including thyroid eye disease.

Cat. No.

A28323

CAS No.

88642-46-0

Cerebroside B

Cerebroside B is a sphingolipid compound that acts as a non-race-specific elicitor, triggering defense responses in rice plants. This compound is instrumental in studying plant immune signaling pathways and can be utilized in research focusing on plant-microbe interactions and stress responses. Its unique properties make it valuable for investigating the mechanisms of defense in agricultural sciences.

Cat. No.

A30052

CAS No.

124753-97-5

C6 Ceramide

Synonyms: C6-Cer; N-Hexanoylsphingosine

C6 Ceramide is a short-chain, cell-permeable ceramide pathway activator that exhibits significant anticancer activity. It enhances miR-29b expression, influencing the progression of multiple myeloma by inhibiting endothelial cell proliferation, migration, and angiogenesis through the Akt signaling pathway. C6 Ceramide demonstrates a range of anti-cancer effects, including cell cycle arrest, induction of apoptosis, and tumor growth inhibition, and can serve as an adjuvant to improve the effectiveness of chemotherapy in drug-resistant cancer cells.

Cat. No.

A30101

CAS No.

63335-25-1

Malabaricone C

Malabaricone C is a noncompetitive inhibitor of sphingomyelin synthase (SMS), demonstrating IC50 values of 3 μM for SMS 1 and 1.5 μM for SMS 2. This compound has been shown to reduce body weight gain, enhance glucose tolerance, and decrease hepatic lipid accumulation, effectively preventing high-fat diet-induced fatty liver in murine models. Additionally, Malabaricone C exhibits anti-inflammatory properties, making it a valuable tool for research into obesity and immune disorders linked to T-cell hyperactivation. Its source is the fruit of Myristica cinnamomea King.

Cat. No.

A30171

CAS No.

54164-50-0

C24:1-Ceramide

C24:1-Ceramide is a naturally occurring sphingolipid that serves as a critical regulator of numerous biological processes, including cell apoptosis, differentiation, and the proliferation of smooth muscle cells. Additionally, it has been shown to inhibit the mitochondrial respiratory chain, impacting energy metabolism. This compound is valuable for research applications focusing on cellular signaling pathways and lipid metabolism.

Cat. No.

A30633

CAS No.

74713-59-0

C8-Ceramide

Synonyms: N-Octanoyl-D-erythro-sphingosine

C8-Ceramide (N-Octanoyl-D-erythro-sphingosine) is a ceramide analog known for its cell permeability and anti-proliferative properties. This compound serves as a promising chemotherapeutic agent and has been shown to stimulate dendritic cells, enhancing T cell responses during viral infections. Additionally, C8-Ceramide induces a moderate activation of protein kinase C (PKC) in vitro, making it a valuable tool for research in immunology and cancer therapeutics.

Cat. No.

A30871

CAS No.

306301-68-8

SKI-I

SKI-I is a selective inhibitor of human sphingosine kinase (SK), exhibiting an IC50 of 1.2 μM for ST-hSK. In addition to its primary action, SKI-I also inhibits hERK2 with an IC50 of 11 μM. This compound demonstrates the ability to induce apoptosis in various tumor cell lines, making it a valuable tool for exploring sphingosine kinase's role in cancer biology and therapeutic research.

Cat. No.

A31059

CAS No.

13018-48-9

Tetraacetylphytosphingosine

Tetraacetylphytosphingosine is an acetylated sphingoid base that functions as a sphingolipid metabolite. It exhibits significant inhibitory effects on angiogenesis by disrupting MAPK activation and reducing intracellular calcium levels. Additionally, Tetraacetylphytosphingosine has been shown to induce apoptosis in HaCaT cells, making it a valuable reagent for studies related to cell signaling, cancer biology, and angiogenesis research.

Cat. No.

A32326

CAS No.

35823-61-1

N-Acetylpsychosine

Synonyms: C2 Galactosylceramide (d18:1/2:0)

N-Acetylpsychosine is an α-galactosylated C2-ceramide that targets glycosphingolipids, exhibiting notable immunostimulatory activity. It serves as a valuable reagent for investigating the mechanisms of apoptosis and elucidating the immune responses activated by dendritic cells (DCs). Researchers can employ N-Acetylpsychosine to gain insights into immune modulation and cell signaling pathways related to glycosphingolipid function.

Cat. No.

A32797

CAS No.

72809-08-6

N-Oleoyl serinol

Synonyms: Oleoyl serinol

N-Oleoyl serinol is a ceramide analog that specifically targets stem cell differentiation. It has been shown to induce apoptosis in residual pluripotent embryoid body-derived cells (EBCs), thereby preventing teratoma formation during stem cell therapy. Additionally, N-Oleoyl serinol enriches EBC cells that undergo neural differentiation post-transplantation, making it a valuable reagent for research in developmental biology and regenerative medicine.

Cat. No.

A32940

CAS No.

3163-37-9

2-Hexadecenal

Synonyms: (E/Z)-16:1 Aldehyde

2-Hexadecenal, a long-chain fatty aldehyde, is a byproduct of sphingolipid metabolism and is implicated in processes such as cytoskeletal reorganization, DNA damage, and apoptosis. This compound modulates reactive oxygen species (ROS) production and promotes apoptosis in polymorphonuclear leukocytes, making it a valuable reagent for studies focusing on lipid metabolism and cellular stress responses. Its role in apoptosis pathways highlights its potential utility in cancer research and inflammation studies.

Cat. No.

A32966

CAS No.

249728-94-7

C6-Phytoceramide

C6-Phytoceramide is a cell-permeable analog of Phytoceramide, targeting cellular pathways involved in apoptosis. This compound has been shown to induce elevated levels of apoptosis in neuroblastoma cells compared to C6-Ceramide. C6-Phytoceramide can be utilized in research focused on cell death mechanisms, neuroblastoma biology, and potential therapeutic applications in cancer treatment.

Cat. No.

A33741

CAS No.

124579-05-1

Ganglioside GM3

Ganglioside GM3 is a key precursor in the biosynthesis of a-, b-, and c-series gangliosides, functioning primarily through its interaction with transmembrane receptors including the epidermal growth factor and insulin receptors. This compound modifies receptor activity by establishing a specialized lipid environment, influencing cellular signaling pathways. Ganglioside GM3 is instrumental for research focused on hypercholesterolemia and related metabolic disorders, contributing to the understanding of lipid metabolism and receptor modulation.

Cat. No.

A36106

CAS No.

189894-79-9

C6 D-Threo Ceramide (d18:1/6:0)

C6 D-Threo Ceramide (d18:1/6:0) is a bioactive sphingolipid that serves as a cell-permeable analog of natural ceramides. This compound has been shown to enhance interleukin-4 (IL-4) production in Phorbol 12-myristate 13-acetate (PMA)-stimulated EL4 T cells, making it a valuable tool for studying immune responses. C6 D-Threo Ceramide is applicable in research focused on sphingolipid biology and its role in cellular signaling pathways.

Cat. No.

A36988

CAS No.

1670-26-4

Sphingosylphosphorylcholine

Sphingosylphosphorylcholine is a bioactive lipid that binds to the OGR1 receptor with a dissociation constant (Kd) of 33.3 nM. This compound promotes delayed phosphorylation of Smad2, enhances α-SMA expression, and activates the TRPM3 channel, demonstrating anti-apoptotic properties and benefits in cardiac hypertrophy and wound healing. With its ability to downregulate apoptosis while upregulating uPA and its receptor uPA-R, Sphingosylphosphorylcholine is valuable in research related to conditions such as atopic dermatitis, promyelocytic leukemia, heart failure, and various cancers, as well as skin wound healing disorders associated with diabetes.

Cat. No.

A38847

CAS No.

4682-48-8

Lactosylceramide (bovine buttermilk)

Synonyms: LacCer (bovine buttermilk)

Lactosylceramide (bovine buttermilk) is a sphingolipid that plays a crucial role in the immune response, particularly on the plasma membranes of human phagocytes. This compound mediates important biological activities such as phagocytosis, chemotaxis, and superoxide generation. It is widely utilized in research applications focusing on immune cell signaling, inflammation, and cellular interactions in various biological systems.

Cat. No.

A39257

CAS No.

87178-48-1

AO-1535

AO-1535 is a semisynthetic monoglycosylceramide that targets the inhibition of reactive oxygen species production in human monocytes and macrophages in response to phorbol ester and chemotactic tetrapeptide stimulation. This compound exhibits anti-inflammatory properties and is valuable for research applications related to inflammatory dermatoses, offering insights into cellular oxidative stress mechanisms.

Cat. No.

A52544

CAS No.

139974-41-7

DL-threo-PPMP hydrochloride

DL-threo-PPMP hydrochloride is a specific inhibitor of sphingosine synthetase in Plasmodium falciparum. By mimicking sphingosine, it effectively inhibits the enzyme's activity, leading to a reduction in sphingomyelin synthase activity and disrupting the parasite's cytoplasmic tubular network. This mechanism not only hampers the proliferation of the malaria parasite but also offers insights into malaria biology and the development of novel antimalarial therapies.

Cat. No.

A53002

CAS No.

149022-18-4

DL-threo-PPMP

DL-threo-PPMP is a potent inhibitor of sphingosine synthetase in Plasmodium falciparum, effectively mimicking the substrate sphingosine to disrupt enzymatic activity. This inhibition leads to a significant reduction in sphingosine synthetase function, resulting in the dismantling of the tubular network of Toxoplasma gondii vacuoles within host cells, thereby hindering the proliferation of the parasite. DL-threo-PPMP serves as a valuable tool for investigating Plasmodium biology and developing novel antimalarial strategies.

Cat. No.

A53210

CAS No.

10016-20-3

α-Cyclodextrin

α-Cyclodextrin is a soluble fiber that primarily targets cell membrane components, depleting sphingolipids and phospholipids. This compound interacts with tubulin and has been shown to enhance cellular defenses against SARS-CoV-2 infection. Additionally, α-Cyclodextrin improves the anticancer efficacy of Curcumin in the treatment of breast, lung, and cervical cancers while also positively influencing body weight and blood lipid profiles. Its multifunctional roles make it a valuable reagent for various biochemical and pharmacological research applications.

Cat. No.

A57733

CAS No.

52725-57-2

alpha-1,4-Galactosyltransferase (LgtC)

Synonyms: A4GALT

alpha-1,4-Galactosyltransferase (LgtC) is an enzyme that functions as a glycosyltransferase targeting glycosphingolipids, specifically catalyzing the transfer of galactose to the alpha-1,4 position of lactosylceramide to produce globotriaosylceramide. This enzyme plays a crucial role in the biosynthesis of P1 blood group antigens, making it valuable for research applications in glycobiology and blood type characterization. Its precise enzymatic activity enables the exploration of glycosylation patterns and associated biological processes.

Cat. No.

A65374

CAS No.

151057-28-2

Sulfo galactosylceramide

Synonyms: (3'-sulfo)Galβ-Cer(d18:1/24:1); N-Nervonoyl Sulfatide; C24:1 Sulfatide

Sulfo galactosylceramide is a glycolipid that serves as a critical component of mature myelin. It has been shown to interact with C-type lectins and immunoglobulin-like receptors, particularly exhibiting high affinity for LMIR5. This compound induces MCP-1 production in basophils and enhances NFAT activation through LMIR5. In research applications, sulfo galactosylceramide demonstrates therapeutic potential by alleviating symptoms and improving survival in mouse models of chronic relapsing-remitting experimental autoimmune encephalomyelitis (EAE), while also reducing inflammatory lesions and infiltrating mononuclear cells in spinal cord tissues.

Cat. No.

A65376

CAS No.

2415078-34-9

1-Deoxydihydroceramide

1-Deoxydihydroceramide functions as a hapten by serving as an endogenous chaperone lipid that facilitates antigen presentation. It binds beneath the antigen, enhancing its interaction with the T cell receptor (TCR) and promoting T cell activation. This compound is valuable for research in immunology, particularly in studies related to T cell responses and antigen processing.

Cat. No.

A65532

CAS No.

241476-71-1

(R)-AAL

(R)-AAL is an immunomodulator that targets sphingosine kinase (SphK), catalyzing the phosphorylation of the compound. This compound has demonstrated the ability to decrease circulating T lymphocytes in rat models, exhibiting an ID50 value of 0.009 mg/kg. (R)-AAL is valuable for research into immune regulation and the modulation of lymphocyte activity.

Cat. No.

A65539

CAS No.

752987-57-8

Biotinylated sphingosine

Synonyms: Biotinyl-Sph

Biotinylated sphingosine is a substrate for sphingosine kinase, primarily targeting SPHK1 and SPHK2. This compound enables the detection of sphingosine kinase phosphorylation activity, making it a valuable tool for studies focused on sphingolipid metabolism and signal transduction pathways. Researchers can leverage biotinylated sphingosine in various applications, including enzyme activity assays and the exploration of sphingosine-related cellular processes.