Fig. 1 · Structure
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Cabamiquine succinate
Antimalarial Agent
Cabamiquine succinate is a potent antimalarial agent that targets multiple life-cycle stages of the Plasmodium parasite, demonstrating an EC50 of 1 nM against P. falciparum 3D7. This compound inhibits protein synthesis by specifically targeting eEF2/CaMKIII, with an EC50 of 2 nM for wild-type PfeEF2. Cabamiquine succinate serves as a valuable tool for research into antimalarial mechanisms and the development of new therapeutic strategies against malaria.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 2444781-71-7 |
| Applications | Antimalarial Agent |
| Formula | C31H37FN4O6 |
| Molecular Weight | 580.65 |
| Synonyms | DDD107498 succinate; DDD-498 succinate; M5717 succinate |
| SMILES | OC(CCC(O)=O)=O.O=C(C1=CC(C2=CC=C(C=C2)CN3CCOCC3)=NC4=CC=C(C=C41)F)NCCN5CCCC5 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.