Fig. 1 · Structure
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Cabamiquine
Antimalarial Agent
Cabamiquine (DDD107498) is a highly effective antimalarial agent that demonstrates potent activity against multiple life-cycle stages of the Plasmodium falciparum parasite, with an EC50 of 1 nM for the 3D7 strain. It exerts its biological effects by inhibiting protein synthesis through the targeting of elongation factor 2 (eEF2) and CaMKIII, exhibiting an EC50 of 2 nM for wild-type Pf-eEF2. This compound is valuable for research applications focused on malaria treatment and the mechanisms of drug action.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 1469439-69-7 |
| Applications | Antimalarial Agent |
| Formula | C27H31FN4O2 |
| Molecular Weight | 462.56 |
| Synonyms | DDD107498; DDD-498; M5717 |
| SMILES | O=C(C1=CC(C2=CC=C(C=C2)CN3CCOCC3)=NC4=CC=C(C=C41)F)NCCN5CCCC5 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.