Fig. 1 · Structure
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CAD031
Neuroprotective Agent
CAD031 is an orally active neuroprotective agent that functions as an activator of the AMPK/ACC1 signaling pathway. This compound can effectively cross the blood-brain barrier, enhancing mitochondrial function by activating AMPK and inhibiting ACC1, which leads to increased ac-CoA levels and a reduction in free fatty acid synthesis. CAD031 demonstrates significant potential in promoting neurogenesis, improving memory, and is applicable in research on Alzheimer's disease and aging-related neurodegenerative disorders. In preclinical studies, CAD031 has shown to enhance memory in mice and stimulate dendritic structure and cell division in the brain's germinal zone.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Activator |
| CAS Number | 2071209-49-7 |
| Applications | Neuroprotective Agent |
| Formula | C18H14F6N2O2 |
| Molecular Weight | 404.31 |
| SMILES | O=C(N(C1=CC=C(C)C=C1C)/N=C/C2=CC=CC(OC(F)(F)F)=C2)C(F)(F)F |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.