Fig. 1 · Structure
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Calmodulin antagonist-1
Calmodulin Antagonist
Calmodulin Antagonist-1 is a selective inhibitor of calmodulin (CaM), designed to hinder calmodulin-activated calcium-dependent phosphodiesterase (PDE) with an IC50 of 66 μM. This compound also exhibits competitive inhibition of trypsin-treated Ca2+-PDE, showcasing an IC50 of 560 μM in relation to cyclic GMP. Its ability to modulate calmodulin activity makes it a valuable tool for investigating calcium signaling pathways and their implications in various biological processes.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 78957-84-3 |
| Applications | Calmodulin Antagonist |
| Formula | C14H18Cl2N2O2S |
| Molecular Weight | 349.28 |
| SMILES | O=S(C1=C2C=CC=C(Cl)C2=CC=C1)(NCCCCN)=O.[H]Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.