Fig. 1 · Structure
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CALP1
Calmodulin Agonist
CALP1 is a potent calmodulin (CaM) agonist that targets the EF-hand/Ca2+-binding site, exhibiting a Kd of 88 µM. This compound effectively inhibits calcium influx and apoptosis with an IC50 of 44.78 µM by blocking the opening of calcium channels. Additionally, CALP1 obstructs glutamate receptor channels and a store-operated nonselective cation channel. Its unique properties enable the activation of CaM-dependent phosphodiesterase activity, making CALP1 valuable for studies on calcium signaling and related neurobiological processes.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Agonist |
| CAS Number | 145224-99-3 |
| Applications | Calmodulin Agonist |
| Formula | C40H75N9O10 |
| Molecular Weight | 842.08 |
| SMILES | [C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CCCCN)C(O)=O)=O)[C@@H](C)C)=O)CC(C)C)=O)[C@H](C)C)=O)[C@@H](C)O)=O)(NC([C@@H](NC([C@H](C(C)C)N)=O)C)=O)[C@H](CC)C |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.