Fig. 1 · Structure
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CALP2
Calmodulin Antagonist
CALP2 is a calmodulin (CaM) antagonist characterized by a Kd of 7.9 µM, demonstrating strong binding to the CaM EF-hand/Ca2+-binding site. This compound effectively inhibits CaM-dependent phosphodiesterase activity, leading to increased intracellular Ca2+ concentrations. CALP2 is known to significantly suppress cell adhesion and degranulation processes, while also serving as a potent activator of alveolar macrophages, making it valuable for research in cellular signaling and immune response.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 261969-04-4 |
| Applications | Calmodulin Antagonist |
| Formula | C68H104N14O13S |
| Molecular Weight | 1357.70 |
| SMILES | [C@H](CC1=CC=CC=C1)(C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC2=CC=CC=C2)C(O)=O)=O)C(C)C)=O)CCSC)=O)C(C)C)=O)CCCCN)=O)NC(CNC([C@@H](NC(CNC([C@H](CC3=CC=CC=C3)NC([C@@H](NC([C@H](C(C)C)N)=O)CCCCN)=O)=O)=O)[C@H](C)C)=O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.