Camptothecin-d5 is a deuterium-labeled derivative of Camptothecin, a potent inhibitor of DNA topoisomerase I with an IC50 of 679 nM. This compound exhibits significant antineoplastic activity against various cancers, including colorectal, breast, lung, and ovarian malignancies. Additionally, Camptothecin modulates hypoxia-inducible factor-1α (HIF-1α) activity by altering microRNA expression patterns in human cancer cells, making it valuable for cancer research applications.
Camptothecin-d5 is a deuterium-labeled derivative of Camptothecin, a potent inhibitor of DNA topoisomerase I with an IC50 of 679 nM. This compound exhibits significant antineoplastic activity against various cancers, including colorectal, breast, lung, and ovarian malignancies. Additionally, Camptothecin modulates hypoxia-inducible factor-1α (HIF-1α) activity by altering microRNA expression patterns in human cancer cells, making it valuable for cancer research applications.
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