Canertinib dihydrochloride

Catalog No.: A11344

EGFR inhibitor

Canertinib dihydrochloride

Canertinib dihydrochloride Chemical Structure

CAS NO. 289499-45-2

Canertinib dihydrochloride (CI-1033 dihydrochloride) is a potent and irreversible EGFR inhibitor; inhibits cellular EGFR and ErbB2 autophosphorylation with IC50s of 7.4 and 9 nM.

Availability: In stock

Package Price Qty
50 mg
$72.00
100 mg
$124.00
500 mg
$368.00
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Biological Activity

Canertinib dihydrochloride (CI-1033 dihydrochloride) is a potent and irreversible EGFR inhibitor; inhibits cellular EGFR and ErbB2 autophosphorylation with IC50s of 7.4 and 9 nM.
In vitro DMSO 88 mg/mL (157.46 mM)
Water 18 mg/mL (32.2 mM)
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 17.89 mL 89.47 mL 178.94 mL
0.5 mM 3.58 mL 17.89 mL 35.79 mL
1 mM 1.79 mL 8.95 mL 17.89 mL
5 mM 0.36 mL 1.79 mL 3.58 mL

*The above data is based on the productmolecular weight 558.86. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11344
Actions Inhibitor
CAS No. 289499-45-2
Formula C24H27Cl3FN5O3
M. Wt 558.86
Purity >98%
Synonyms CI-1033 dihydrochloride; PD-183805 dihydrochloride
SMILES C=CC(NC1=CC2=C(N=CN=C2C=C1OCCCN3CCOCC3)NC4=CC=C(C(Cl)=C4)F)=O.[H]Cl.[H]Cl
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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