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Canertinib dihydrochloride (CI-1033 dihydrochloride) is a potent and irreversible EGFR inhibitor; inhibits cellular EGFR and ErbB2 autophosphorylation with IC50s of 7.4 and 9 nM.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 17.89 mL | 89.47 mL | 178.94 mL |
| 0.5 mM | 3.58 mL | 17.89 mL | 35.79 mL |
| 1 mM | 1.79 mL | 8.95 mL | 17.89 mL |
| 5 mM | 0.36 mL | 1.79 mL | 3.58 mL |
*The above data is based on the productmolecular weight 558.86. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A11344 |
|---|---|
| Actions | Inhibitor |
| M. Wt | 558.86 |
| Formula | C24H27Cl3FN5O3 |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 289499-45-2 |
| Synonyms | CI-1033 dihydrochloride; PD-183805 dihydrochloride |
| SMILES | C=CC(NC1=CC2=C(N=CN=C2C=C1OCCCN3CCOCC3)NC4=CC=C(C(Cl)=C4)F)=O.[H]Cl.[H]Cl |
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