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Canertinib dihydrochloride (CI-1033 dihydrochloride) is a potent and irreversible EGFR inhibitor; inhibits cellular EGFR and ErbB2 autophosphorylation with IC50s of 7.4 and 9 nM.
| In vitro | DMSO | 88 mg/mL (157.46 mM) | |
| Water | 18 mg/mL (32.2 mM) | ||
| Ethanol | Insoluble | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 17.89 mL | 89.47 mL | 178.94 mL |
| 0.5 mM | 3.58 mL | 17.89 mL | 35.79 mL |
| 1 mM | 1.79 mL | 8.95 mL | 17.89 mL |
| 5 mM | 0.36 mL | 1.79 mL | 3.58 mL |
*The above data is based on the productmolecular weight 558.86. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A11344 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 289499-45-2 |
| Formula | C24H27Cl3FN5O3 |
| M. Wt | 558.86 |
| Purity | >98% |
| Synonyms | CI-1033 dihydrochloride; PD-183805 dihydrochloride |
| SMILES | C=CC(NC1=CC2=C(N=CN=C2C=C1OCCCN3CCOCC3)NC4=CC=C(C(Cl)=C4)F)=O.[H]Cl.[H]Cl |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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