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Cantharidic acid

Protein Phosphatase Inhibitor

Cantharidic acid is a selective inhibitor of protein phosphatase 2A (PP2A) and protein phosphatase 1 (PP1). It exhibits significant biological activity by reducing cell viability and inducing G1 phase cell cycle arrest, as well as promoting apoptosis in NPC-39 and HONE-1 cancer cell lines. This compound functions through the upregulation of key mitogen-activated protein kinase (MAPK) pathways, including ERK1/2, p38, and JNK1/2, making it valuable for research in cancer biology and therapeutic development.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	28874-45-5
Applications	Protein Phosphatase Inhibitor
Formula	C₁₀H₁₄O₅
Molecular Weight	214.22
SMILES	OC([C@@]([C@@]1(C)C(O)=O)([C@@H]2O[C@H]1CC2)C)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.