Capeserod is a potent agonist of the serotonin 5-HT4 receptor, exhibiting a Ki of 0.6 nM. It is known to enhance the expression of key proteins such as phosphorylated cAMP-response element binding protein (p-CREB), vascular endothelial growth factor (VEGF), brain-derived neurotrophic factor (BDNF), and B cell lymphoma-2 (Bcl-2) in the hippocampus. Capeserod demonstrates potential antidepressant-like efficacy in Wistar rat models, making it a valuable tool for research in neuropsychiatric disorders and serotonin signaling pathways.
Capeserod is a potent agonist of the serotonin 5-HT4 receptor, exhibiting a Ki of 0.6 nM. It is known to enhance the expression of key proteins such as phosphorylated cAMP-response element binding protein (p-CREB), vascular endothelial growth factor (VEGF), brain-derived neurotrophic factor (BDNF), and B cell lymphoma-2 (Bcl-2) in the hippocampus. Capeserod demonstrates potential antidepressant-like efficacy in Wistar rat models, making it a valuable tool for research in neuropsychiatric disorders and serotonin signaling pathways.
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