Fig. 1 · Structure
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Capeserod
5-HT Receptor Agonist
Capeserod is a potent agonist of the serotonin 5-HT4 receptor, exhibiting a Ki of 0.6 nM. It is known to enhance the expression of key proteins such as phosphorylated cAMP-response element binding protein (p-CREB), vascular endothelial growth factor (VEGF), brain-derived neurotrophic factor (BDNF), and B cell lymphoma-2 (Bcl-2) in the hippocampus. Capeserod demonstrates potential antidepressant-like efficacy in Wistar rat models, making it a valuable tool for research in neuropsychiatric disorders and serotonin signaling pathways.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Agonist |
| CAS Number | 769901-96-4 |
| Applications | 5-HT Receptor Agonist |
| Formula | C23H25ClN4O4 |
| Molecular Weight | 456.92 |
| Synonyms | SL65.0155 free base |
| SMILES | O=C1OC(C2=C3OCCOC3=C(N)C(Cl)=C2)=NN1C4CCN(CC4)CCC5=CC=CC=C5 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.