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Caplacizumab

Caplacizumab (ALX-0681) is a humanized nanobody targeting the von Willebrand factor (vWF), designed to disrupt the interaction between vWF and platelet glycoprotein Ibα. By inhibiting this binding, Caplacizumab effectively prevents vWF-mediated platelet adhesion, thereby reducing the formation of microthrombi. This agent is particularly useful for research focused on thrombotic thrombocytopenic purpura (TTP), offering a valuable tool for investigating the mechanisms and potential treatments of this condition.

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Product Details

Manufacturer Adooq Bioscience
CAS Number 915810-67-2
Molecular Weight 27876
Synonyms ALX-0681; ALX-0081

Storage

Store lyophilized at -20°C, keep desiccated.
In lyophilized form, the antibody is stable for 36 months.
After reconstitution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Customer Questions
Biosimilar antibodies are research-grade recombinant antibodies designed to closely resemble approved therapeutic antibodies in terms of amino acid sequence, structural characteristics, and biological activity. These antibodies are generated using recombinant expression technologies and retain the same variable regions as their corresponding reference therapeutics, thereby preserving target specificity and binding affinity. Owing to these properties, biosimilar antibodies serve as reliable and cost-effective research reagents for applications in drug discovery, pharmacological studies, and basic biomedical research. Research-grade biosimilar antibodies have been successfully expressed and functionally validated against a wide range of widely studied targets. These antibodies can be directly utilized as positive control reagents in drug discovery programs, as well as reference tools for rapid verification of the biological functions of target proteins in biochemical and cellular assays.
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