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Carbosulfan-d18

Catalog No.: A52499
Stable Isotope
Carbosulfan-d18 is a deuterium-labeled derivative of Carbosulfan, targeting cytochrome P450 enzymes. It exhibits potent inhibition of CYP3A4 while demonstrating moderate inhibition of CYP1A1/2 and CYP2C19 in pooled human liver microsomes. This reagent is valuable for studies exploring the metabolic activation of Carbosulfan, particularly in human liver systems.
Carbosulfan-d18 1189903-75-0 Stable Isotope
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionCarbosulfan-d18 is a deuterium-labeled derivative of Carbosulfan, targeting cytochrome P450 enzymes. It exhibits potent inhibition of CYP3A4 while demonstrating moderate inhibition of CYP1A1/2 and CYP2C19 in pooled human liver microsomes. This reagent is valuable for studies exploring the metabolic activation of Carbosulfan, particularly in human liver systems.
Product Information
Catalog NumA52499
FormulaC20H14D18N2O3S
Molecular Weight398.66
CAS Number1189903-75-0
SMILES[2H]C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])N(C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])[2H])SN(C)C(OC1=C2C(CC(C)(O2)C)=CC=C1)=O
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Isotope-Labeled Compounds