Fig. 1 · Structure
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Catharanthine
Ca2+ Channel Inhibitor
Catharanthine, a potent inhibitor of voltage-operated L-type Ca2+ channels (VOCC), demonstrates significant activity in the modulation of calcium ion influx. With IC50 values of 220 μM and 8 μM in cardiomyocytes and vascular smooth muscle cells (VSMCs), respectively, it effectively lowers blood pressure and heart rate. Furthermore, Catharanthine exhibits anti-cancer properties, making it valuable for various research applications in cardiovascular and cancer studies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2468-21-5 |
| Applications | Ca2+ Channel Inhibitor |
| Formula | C21H24N2O2 |
| Molecular Weight | 336.43 |
| Synonyms | (+)-3,4-Didehydrocoronaridine |
| SMILES | O=C([C@@]12C3=C(CC[N@](C4)[C@]1([H])C(CC)=C[C@@]4([H])C2)C5=CC=CC=C5N3)OC |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.