Fig. 1 · Structure
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CaV1.3 antagonist-1
CaV1.3 Antagonist
CaV1.3 antagonist-1 is a selective antagonist of the CaV1.3 L-type calcium channel, exhibiting an IC50 value of 1.7 μM. This compound inhibits CaV1.3 L-type calcium channels over 600-fold more potently than CaV1.2 channels, indicating its high specificity. Due to its unique profile, CaV1.3 antagonist-1 holds potential for research in neurodegenerative diseases, particularly in the context of Parkinson's disease.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 1391385-57-1 |
| Applications | CaV1.3 Antagonist |
| Formula | C17H19ClN2O3 |
| Molecular Weight | 334.80 |
| SMILES | O=C1N(C2CCCC2)C(CC(N1CCC3=CC=CC(Cl)=C3)=O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.