Fig. 1 · Structure
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CB 3717
Thymidylate Synthase Inhibitor
CB 3717 is a selective inhibitor of thymidylate synthase, competing with 5,10-methylenetetrahydrofolate (Ki = 4.9 X 10(-9) M). This compound also inhibits human dihydrofolate reductase, interacting competitively with dihydrofolate (Ki = 2.3 X 10(-8) M). In studies using WI-L2 human lymphoblastoid cells, CB 3717 significantly decreased dTTP levels while increasing dUMP levels, disrupting nucleotide metabolism. Its cytotoxic effects can be counteracted by thymidine supplementation, establishing thymidylate synthase as a rate-limiting factor in cellular proliferation. The timing of thymidine rescue is crucial, as delays beyond 8 hours lead to heightened toxicity in treated cells.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 76849-19-9 |
| Applications | Thymidylate Synthase Inhibitor |
| Formula | C24H23N5O6 |
| Molecular Weight | 477.47 |
| Synonyms | PDDF |
| SMILES | O=C1C2=CC(CN(C3=CC=C(C=C3)C(N[C@H](C(O)=O)CCC(O)=O)=O)CC#C)=CC=C2NC(N)=N1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.