Synthases/Synthetases

Cat. No.

A10776

CAS No.

112887-68-0

Raltitrexed

Synonyms: Tomudex; TDX; ZD 1694

Raltitrexed (Tomudex) is an inhibitor of thymidylate synthase and also is one of the strongest antimetabolites in use.

Cat. No.

A13270

CAS No.

235114-32-6

Micafungin

Micafungin (Mycamine; FK463) is an echinocandin antifungal drug which can inhibit 1,3-beta-D-glucan synthase.

Cat. No.

A13436

CAS No.

166663-25-8

Anidulafungin

Anidulafungin is a semi-synthetic cyclic lipopeptide belonging to the echinocandin class that was reported in 1995 and commercially developed by Eli Lilly. Anidulafungin inhibits the synthesis of ??-(1,3)-D-glucan, an essential component of the cell wall of susceptible fungi and is extensively referenced in the literature with over 400 citations.

Cat. No.

A10050

CAS No.

121268-17-5

Alendronate sodium hydrate

Synonyms: MK-217,G-704650; Fosamax; Adronat

Alendronate is a nitrogen-containing bisphosphonate that is commonly used in the treatment of osteoporosis and other metabolic bone diseases.

Cat. No.

A11113

CAS No.

135575-42-7

Pneumocandin B0

Pneumocandin B0 is the major analogue of a family of lipopeptides isolated from several species of several different genera, notably Cryptosporiopsis, Glarea and Pezicula. Pneumocandin B0 is a potent antifungal and acts by inhibition of the synthesis of β-(1,3)-D-glucan, an essential component of the cell wall of susceptible fungi.

Cat. No.

A12992

CAS No.

162641-16-9

HQL-79

HQL-79 is a selective inhibitor of hematopoietic prostaglandin D (PGD) synthase, that structurally is a synthetic tetrazole compound originally prepared as a possible antihistamine.

Cat. No.

A13261

CAS No.

152946-68-4

Nolatrexed Dihydrochloride

Synonyms: AG 337; Thymitaq

Nolatrexed Dihydrochloride is an antifolate thymidylate synthase inhibitor.

Cat. No.

A13269

CAS No.

162808-62-0

Caspofungin

Synonyms: Cancidas

Caspofungin is an antifungal medicine. It is used to help the body overcome serious fungus infections, including Candida and Aspergillosis infections. It is also used to treat serious fungus infections when other medicines (e.g., amphotericin B, itraconazole) have failed.

Cat. No.

A13483

CAS No.

182959-33-7

YM-53601

YM-53601 is a novel squalene synthase inhibitor. It suppresses lipogenic biosynthesis and lipid secretion in rodents.

Cat. No.

A13999

CAS No.

76896-80-5

Triacsin C

Synonyms: WS1228A; FR 900190

Triacsin C, originally isolated from Streptomyces sp., is an inhibitor of long fatty acid acyl-CoA synthetase (IC50 = 6.3 uM in Raji cells).

Cat. No.

A14083

CAS No.

139987-54-5

OSI-7904L

Synonyms: GW1843; 1843U89; OSI-7904

OSI-7904L is a noncompetitive inhibitor of thymidylate synthase (TS), functioning as an antifolate compound and a substrate for folylpolyglutamate synthetase. This compound exhibits significant cytotoxicity against various solid tumor cell lines, demonstrating its potential in cancer research and therapeutic applications. The cytotoxic effects of OSI-7904L can be selectively mitigated by folic acid, highlighting its mechanism of action and potential for targeted treatment strategies.

Cat. No.

A14937

CAS No.

880149-29-1

Bismuth Subcitrate Potassium

Bismuth Subcitrate is an antibiotic used to treat stomach ulcers associated with Helicobacter pylori, a bacterial infection.

Cat. No.

A14938

CAS No.

14882-18-9

Bismuth Subsalicylate

Bismuth Subsalicylate is the active ingredient in Pepto-Bismol and inhibits prostaglandin G/H Synthase 1/2.

Cat. No.

A15442

CAS No.

491833-30-8

Genz-123346 free base

Synonyms: Genz123346

Genz-123346 free base is an inhibitor of GL1 synthase that blocks the conversion of ceramide to GL1; IC50 for GM1 inhibition is 14 nM.

Cat. No.

A16202

CAS No.

5072-26-4

Buthionine Sulphoximine

Synonyms: NSC-326231; BSO

Buthionine Sulphoximine is a gamma-glutamylcysteine synthetase inhibitor potentially for the treatment of solid tumors.

Cat. No.

A16329

CAS No.

1234563-16-6

Epetraborole hydrochloride

Synonyms: GSK-2251052; Epetraborole HCl

AN3365 is a potent and selective leucyl-tRNA synthetase inhibitor.

Cat. No.

A17267

CAS No.

1220-83-3

Sulfamonomethoxine

Synonyms: Sulfamonmethoxine

Sulfamonmethoxine is a competitive inhibitor of dihydropteroate synthetase, blocking the synthesis of folic acid.

Cat. No.

A18398

CAS No.

2170696-76-9

LysRs-IN-2

LysRs-IN-2 is a lysyl-tRNA synthetase (KRS) inhibitor with IC50s of 0.015 μM and 0.13 μM for Plasmodium falciparum lysyl-tRNA synthetase (PfKRS) and Cryptosporidium parvum lysyl-tRNA synthetase (CpKRS), respectively.

Cat. No.

A19543

CAS No.

112921-11-6

GlyRS-IN-1

GlyRS-IN-1 is a glycyl-tRNA synthase (GlyRS) inhibitor extracted from patent WO 2017066459 A1. GlyRS-IN-1 can also inhibit the growth of bacteria.

Cat. No.

A19550

CAS No.

1023043-30-2

ATP synthase inhibitor 1

ATP synthase inhibitor 1 is a potent inhibitor of c subunit of the F1/FO-ATP synthase complex, inhibits mitochondrial permeability transition pore (mPTP) opening, does not affect ATP levels.

Cat. No.

A19580

CAS No.

288591-93-5

Leu-AMS

Leu-AMS (compound 6), a leucine analogue, is a potent inhibitor of leucyl-tRNA synthetase (LRS) with an IC50 of 22.34 nM, which inhibits the catalytic activity of LRS but did not affect the leucine-induced mTORC1 activation.

Cat. No.

A20248

CAS No.

301351-95-1

Arg-AMS

Arg-AMS is a potent nanomolar inhibitor of arginyl tRNA synthetase, which displays tightly bound inhibitory characteristics for the A-domains in non-ribosomal peptide synthetases (NRPS) enzymes.

Cat. No.

A20260

CAS No.

209543-57-7

Gln-AMS

Gln-AMS is an aminoacyl-tRNA synthetases (AARS) inhibitor, which binds the A-domain within the NRPS enzymes.

Cat. No.

A21637

CAS No.

1375105-96-6

FAS-IN-1

FAS-IN-1 is a potent inhibitor of Fatty acid synthase (FAS) wtih IC50 of 10 nM, extracted from Patnet WO2012/064642Al.

Cat. No.

A33105

CAS No.

87614-40-2

Diazaquinomycin A

Diazaquinomycin A is a potent inhibitor of thymidylate synthase, a key enzyme involved in DNA synthesis. This diaza-anthracene antibiotic induces DNA damage and triggers cellular responses such as cell cycle arrest and apoptosis, evidenced by the cleavage of PARP. It serves as a valuable tool in cancer research and studies focused on therapeutic strategies targeting DNA replication and repair mechanisms.