CB5083

Catalog No.: A15827

p97 inhibitor

CB5083

CB5083 Chemical Structure

CAS NO. 1542705-92-9

CB-5083 is a novel first in class, potent orally bio-available p97 inhibitor that disrupts cellular protein homeostasis and demonstrates anti-tumor activity in solid and hematological models .

Availability: In stock

Package Price Qty
5 mg
$45.00
10 mg
$85.00
25 mg
$175.00
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Biological Activity

CB-5083 is a novel first in class, potent orally bio-available p97 inhibitor that disrupts cellular protein homeostasis and demonstrates anti-tumor activity in solid and hematological models .
Targets
p97 AAA ATPase
11 nM
In vitro (25°C) DMSO 74 mg/mL (178.97 mM)
Water Insoluble
Ethanol Warmed: 12 mg/mL (29.02 mM)
In vivo 0.5% CMC Na+5% Tween 80 28 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 24.19 mL 120.95 mL 241.9 mL
0.5 mM 4.84 mL 24.19 mL 48.38 mL
1 mM 2.42 mL 12.09 mL 24.19 mL
5 mM 0.48 mL 2.42 mL 4.84 mL

*The above data is based on the productmolecular weight 413.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A15827
Actions Inhibitor
CAS No. 1542705-92-9
Formula C24H23N5O2
M. Wt 413.4
Purity >98%
Synonyms CB-5083, CB 5083
SMILES CC1=CC2=C(C=CC=C2N1C3=NC4=C(COCC4)C(=N3)NCC5=CC=CC=C5)C(=O)N
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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