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Cbl-b-IN-11

Cbl-b/c-Cbl Inhibitor

Cbl-b-IN-11 is a specific inhibitor of casitas B-lineage lymphoma-b (Cbl-b) and c-Cbl, exhibiting IC50 values of 6.4 nM and 6.1 nM, respectively. This compound effectively modulates Cbl-b signaling pathways, making it a valuable tool for investigating immune responses and T cell regulation. Its precise inhibition of Cbl proteins supports research in cancer immunotherapy and autoimmune diseases.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	2815225-15-9
Applications	Cbl-b/c-Cbl Inhibitor
Formula	C₃₁H₃₅F₅N₆O
Molecular Weight	602.64
SMILES	O=C1C2=C(CN1C3=CC(NCC)=CC(C4(CC(F)(C4)F)CC5=NN=CN5C)=C3)C(C(F)(F)F)=CC(CNC6(CCC6)C)=C2

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.