Fig. 1 · Structure
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Cbl-b-IN-12
CBL-B Inhibitor
Cbl-b-IN-12 is a selective inhibitor of casitas B-lineage lymphoma-b (CBL-B) with an IC50 of less than 100 nM. This compound is essential for modulating immune responses, making it a valuable tool in research focused on cancer immunotherapy and autoimmune diseases. Its specific inhibition of CBL-B facilitates the enhancement of T-cell activation, providing insights into therapeutic strategies that target immune regulation.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2851871-29-7 |
| Applications | CBL-B Inhibitor |
| Formula | C28H29F3N6O2 |
| Molecular Weight | 538.56 |
| SMILES | O=C1N(C2=CC=CC(C3(CC4=NN=CN4C)COC3)=C2)C=C5C(C(F)(F)F)=CC(CN6CCC7(CC7)C6)=CN15 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.