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Cbl-b-IN-6

Cbl-b/c-Cbl Inhibitor

Cbl-b-IN-6 is a selective inhibitor of casitas B-lineage lymphoma-b (Cbl-b) and c-Cbl. With IC50 values of 6.7 nM and 5.2 nM, respectively, this compound effectively modulates Cbl-b signaling pathways. Cbl-b-IN-6 is valuable for research applications exploring immune regulation and cancer biology, particularly in the context of T cell activation and differentiation.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	2815221-33-9
Applications	Cbl-b/c-Cbl Inhibitor
Formula	C₃₀H₃₂F₅N₅O
Molecular Weight	573.60
SMILES	FC(F)(C1)CC1(C2=CC(N3CC4=C(C(F)(F)F)C=C([C@H](C)NC5(CCC5)C)C=C4C3=O)=CC=C2)CC6=NN=CN6C

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.