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Cbl-b-IN-7

Cbl-b/c-Cbl Inhibitor

Cbl-b-IN-7 is a potent inhibitor of casitas B-lineage lymphoma-b (Cbl-b) and c-Cbl, exhibiting IC50 values of 6.7 nM and 5.2 nM, respectively. This compound effectively disrupts the activity of Cbl-b and c-Cbl, targeting pathways involved in immune regulation and cell signaling. Cbl-b-IN-7 is particularly relevant in studies related to immune response modulation and cancer research, providing valuable insights into therapeutic strategies for immune-related diseases.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	2815221-35-1
Applications	Cbl-b/c-Cbl Inhibitor
Formula	C₂₉H₃₁F₄N₅O₂
Molecular Weight	557.58
SMILES	F[C@@H](C1=NN=CN1C)C2(C3=CC(N4CC5=C(C(F)(F)F)C=C([C@H](C)NC6(CCC6)C)C=C5C4=O)=CC=C3)COC2

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.