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Cbl-b-IN-8

Cbl-b/c-Cbl Inhibitor

Cbl-b-IN-8 is a potent inhibitor of casitas B-lineage lymphoma-b (Cbl-b) and c-Cbl, exhibiting IC50 values of 5.5 nM and 7.8 nM, respectively. This compound is valuable for research applications focusing on immune regulation and signal transduction pathways influenced by Cbl proteins. Its effectiveness in modulating Cbl-b and c-Cbl activity makes it a useful tool for studying cancer biology and therapeutic interventions targeting these pathways.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	2815223-33-5
Applications	Cbl-b/c-Cbl Inhibitor
Formula	C₃₅H₄₄F₃N₇O₃
Molecular Weight	667.76
SMILES	O=C1C2=CC(CN3[C@H](CN(CC3)C)C(C)C)=CC(C(F)(F)F)=C2CN1C4=CC(C5(COC5)CC6=NN=CN6C)=CC(OC7CCCC7)=N4

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.