Fig. 1 · Structure
Documents & Downloads
Cbl-b-IN-9
Cbl-b/c-Cbl Inhibitor
Cbl-b-IN-9 is a selective inhibitor of casitas B-lineage lymphoma-b (Cbl-b) and c-Cbl, exhibiting IC50 values of 5.6 nM and 4.7 nM, respectively. This compound modulates immune signaling pathways by inhibiting the ubiquitin ligase activity of Cbl-b and c-Cbl, making it a valuable tool for studying immune responses and T cell activation. Research applications include investigations into cancer immunotherapy and the regulation of immune checkpoints.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2815223-41-5 |
| Applications | Cbl-b/c-Cbl Inhibitor |
| Formula | C30H33F3N6O2 |
| Molecular Weight | 566.62 |
| SMILES | O=C1C2=C(CN1C3=CC(C4(CC5=NN=CN5C)COC4)=CC(C6CC6)=N3)C(C(F)(F)F)=CC(CNC7(CCC7)C)=C2 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.