Fig. 1 · Structure
Documents & Downloads
CBP/p300-IN-10
EP300/CREBBP Inhibitor
CBP/p300-IN-10 is a potent inhibitor of the histone acetyltransferases EP300 and CREBBP, demonstrating IC50 values of 26 nM and 39 nM, respectively. This compound effectively inhibits the activities of these enzymes, which play a crucial role in gene regulation and oncogenesis. CBP/p300-IN-10 is applicable for research focused on anticancer mechanisms and the modulation of histone acetylation in various cancer models.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2259641-71-7 |
| Applications | EP300/CREBBP Inhibitor |
| Formula | C25H24F5N5O3 |
| Molecular Weight | 537.48 |
| SMILES | O=C(N1[C@H](C[C@H](C1)F)C(NC2=CC=C(NN=C3)C3=N2)=O)C4(C5=CC=C(C=C5)OC(F)F)CCC(F)(CC4)F |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.