CBP/p300-IN-12

Name: CBP/p300-IN-12
Brand: Adooq Bioscience
SKU: A24433
Rating: 5 (288 reviews)

Catalog No.: A24433

p300/CBP inhibitor

CBP/p300-IN-12 is a potent and selective covalent inhibitor of the histone acetyltransferases p300 and CBP, with an IC₅₀ of 166 nM for p300. It reduces H3K27Ac levels in PC-3 cells with an EC₅₀ of 37 nM and forms a covalent adduct with cysteine residue C1450.

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CBP/p300-IN-12 2738688-57-6 p300/CBP inhibitor

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Grouped product items
Size	Price	Stock
5mg	$765.00	In stock
10mg	$1,318.00	In stock
50mg	$3,910.00	In stock
100mg	$7,650.00	In stock
Bulk Size	Bulk Discount

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Data Sheet SDS

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Biological Activity

Description	CBP/p300-IN-12 is a potent and selective covalent inhibitor of the histone acetyltransferases p300 and CBP, with an IC₅₀ of 166 nM for p300. It reduces H3K27Ac levels in PC-3 cells with an EC₅₀ of 37 nM and forms a covalent adduct with cysteine residue C1450.

Product Information

Catalog Num	A24433
Formula	C33H29F4N5O6
Molecular Weight	667.61
CAS Number	2738688-57-6
SMILES	C=CC(NC1=CC=CC(NC(NC2=CC3=C([C@]4(OC(N(CC(N(CC5=CC=C(F)C=C5)[C@@H](C)C(F)(F)F)=O)C4=O)=O)CC3)C=C2)=O)=C1)=O
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 1 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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