Fig. 1 · Structure
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CBT-295
ATX Inhibitor
CBT-295 is an orally active inhibitor of autotaxin (ATX), a key enzyme implicated in various inflammatory processes. This compound significantly decreases inflammatory cytokines such as TGF-β, TNF-α, and IL-6, while also lowering bile duct proliferation marker CK-19 and mitigating liver fibrosis. CBT-295's ability to reverse liver fibrosis correlates with reduced blood and brain ammonia levels, as well as diminished neuroinflammation caused by ammonia. It presents a valuable tool for research focused on liver cirrhosis and associated encephalopathy.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1623794-90-0 |
| Applications | ATX Inhibitor |
| Formula | C18H20ClN3O |
| Molecular Weight | 329.82 |
| SMILES | O=C1C=C(C)N(CCCCC)C2=NC(C3=CC=C(Cl)C=C3)=CN12 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.