cCF10 is a peptide sex pheromone that facilitates the transfer of the conjugative plasmid pCF10 from donor to recipient bacterial cells. Its mechanism involves activation of the Opp transport system, allowing cCF10 to enter the cells and inhibit the accumulation of (p)ppGpp, a signaling molecule involved in stress responses. By maintaining a metabolically active state in bacteria, cCF10 effectively reduces the generation of persister cells, making it a valuable tool for research into bacterial conjugation and cell response dynamics.
cCF10 is a peptide sex pheromone that facilitates the transfer of the conjugative plasmid pCF10 from donor to recipient bacterial cells. Its mechanism involves activation of the Opp transport system, allowing cCF10 to enter the cells and inhibit the accumulation of (p)ppGpp, a signaling molecule involved in stress responses. By maintaining a metabolically active state in bacteria, cCF10 effectively reduces the generation of persister cells, making it a valuable tool for research into bacterial conjugation and cell response dynamics.
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