Fig. 1 · Structure
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CCT365623 hydrochloride
Lysyl Oxidase Inhibitor
CCT365623 hydrochloride is a highly selective inhibitor of lysyl oxidase (LOX), exhibiting an IC50 value of 0.89 μM. This compound effectively suppresses EGF-induced phosphorylation of EGFR (pY1068) and AKT, highlighting its potential in modulating signaling pathways associated with cancer progression. It demonstrates favorable pharmacokinetic properties and is well tolerated, making it suitable for various biological research applications, particularly in studies of fibrosis and tumor microenvironment modulation.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2126136-98-7 |
| Applications | Lysyl Oxidase Inhibitor |
| Formula | C18H18ClNO4S3 |
| Molecular Weight | 443.99 |
| SMILES | NCC1=CC=C(S(=O)(C2=CC(C3=CC=CC=C3)=CC(S(=O)(C)=O)=C2)=O)S1.Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.