We use analytics and advertising cookies, which you can accept or reject; see our privacy policy.

Current choice:

DYRK

DYRK inhibitors act on dual-specificity tyrosine phosphorylation-regulated kinases (DYRKs) in cell growth. The first family member, Dyrk, was described in 1996 as a kinase whose activity depends on tyrosine residues in its activation loop. DYRK1A lies in the Down syndrome critical region of chromosome 21, and DYRK1B is studied in cell quiescence. The beta-carboline alkaloid harmine inhibits DYRK1A, as shown in a 2007 kinase selectivity screen. AZ191 preferentially inhibits DYRK1B, LDN-192960 targets DYRK2, and GSK-626616 is listed as a DYRK3 inhibitor. The set also contains inhibitors of related targets such as homeodomain-interacting protein kinase 2 (HIPK2) and mitotic kinesin-like protein 2 (MKLP-2).

2 Items

  • Woodtide
    Cat. No.
    A35087
    CAS No.
    634592-23-7

    Woodtide

    Woodtide is a specific substrate for the DYRK family of kinases, derived from the phosphorylation site sequence of FKHR. This reagent is utilized in biochemical assays to investigate DYRK kinase activity and regulation, facilitating studies on cellular signaling pathways and developmental processes. Its application is crucial for researchers exploring the roles of DYRK kinases in various biological contexts, including cancer and neurodegenerative diseases.

    View Details

    Out of stock

    All 3 sizes
  • PROTAC DYRK2 degrader 1
    Cat. No.
    A84593
    CAS No.
    3061366-76-2

    PROTAC DYRK2 degrader 1

    PROTAC DYRK2 degrader 1 is a selective degrader targeting DYRK2, functioning through the ubiquitin-proteasome system. It exhibits DC50 values of 1.607 μM in MDA-MB-231 cells and 3.265 μM in HeLa cells, effectively inducing DYRK2 degradation. This compound is valuable for research focused on triple-negative breast cancer and cervical cancer, facilitating the exploration of targeted protein degradation mechanisms in these malignancies.

    View Details

    Out of stock

    All 3 sizes

2 Items

Added to your cart

View Cart Checkout

    Loading...