We use analytics and advertising cookies, which you can accept or reject; see our privacy policy.

Current choice:

c-Myc

c-Myc inhibitors act on the MYC transcription factor, a central regulator of cell growth and proliferation. The MYC proto-oncogene protein binds DNA only as a heterodimer with MYC-associated factor X (MAX), a partnership described in 1991. MYC-MAX dimers recognize E-box sequences and regulate genes for ribosome biogenesis, metabolism and cell cycle progression. Amplification, chromosomal translocation or upstream signaling deregulates MYC in many tumor types. Because MYC has no defined ligand-binding pocket, compounds approach it in different ways. 10058-F4, 10074-G5 and MYCi975 are small molecules that interfere with MYC-MAX dimerization. IZCZ-3 is described as a MYC transcription inhibitor that binds a G-quadruplex in the MYC promoter, and related ligands are listed under G-quadruplex.

2 Items

  • Y502-2304
    Cat. No.
    A32290
    CAS No.
    741278-95-5

    Y502-2304

    Y502-2304 is a potent c-Myc G-quadruplex stabilizer that exhibits significant antiproliferative activity in multiple myeloma (MM) cells. It effectively downregulates both c-Myc mRNA and protein expression, leading to the induction of apoptosis characterized by increased γH2AX levels and elevated reactive oxygen species (ROS). Additionally, Y502-2304 disrupts mitochondrial function and demonstrates a marked inhibition of tumor growth in xenograft models of MM. This compound is suitable for various research applications focused on elucidating the molecular mechanisms underlying multiple myeloma.

    View Details

    Out of stock

    All 3 sizes
  • GQC-05
    Cat. No.
    A32687
    CAS No.
    501662-77-7

    GQC-05

    Synonyms: NSC 338258

    GQC-05 is a selective c-Myc G-quadruplex (c-Myc G4) stabilizer that demonstrates potent activity with KD values ranging from 0.1 to 1.43 μM. This compound effectively reduces c-Myc expression, leading to the induction of apoptosis in cancer cells. GQC-05 serves as a valuable tool in cancer research, particularly in studying conditions such as Burkitt lymphoma.

    View Details

    Out of stock

    All 3 sizes

2 Items

Added to your cart

View Cart Checkout

    Loading...