c-Myc

Cat. No.

A23988

MDEG-541

MDEG-541 is a potent PROTAC degrader targeting the MYC-MAX complex, derived from the MYC-MAX dimerization inhibitor 10058-F4 (28RH) and thalidomide as the cereblon-recruiting ligand. It exhibits strong antiproliferative activity and reduces the expression of key oncogenic and regulatory proteins, including GSPT1, MYC, GSPT2, and PLK1. MDEG-541 is a valuable tool for studying MYC-driven cancers and targeted protein degradation strategies.

Cat. No.

A32290

CAS No.

741278-95-5

Y502-2304

Y502-2304 is a potent c-Myc G-quadruplex stabilizer that exhibits significant antiproliferative activity in multiple myeloma (MM) cells. It effectively downregulates both c-Myc mRNA and protein expression, leading to the induction of apoptosis characterized by increased γH2AX levels and elevated reactive oxygen species (ROS). Additionally, Y502-2304 disrupts mitochondrial function and demonstrates a marked inhibition of tumor growth in xenograft models of MM. This compound is suitable for various research applications focused on elucidating the molecular mechanisms underlying multiple myeloma.

Cat. No.

A32687

CAS No.

501662-77-7

GQC-05

Synonyms: NSC 338258

GQC-05 is a selective c-Myc G-quadruplex (c-Myc G4) stabilizer that demonstrates potent activity with KD values ranging from 0.1 to 1.43 μM. This compound effectively reduces c-Myc expression, leading to the induction of apoptosis in cancer cells. GQC-05 serves as a valuable tool in cancer research, particularly in studying conditions such as Burkitt lymphoma.

Cat. No.

A53674

CAS No.

57-97-6

DMBA

Synonyms: 7,12-DMBA; 7,12-Dimethylbenzanthracene

DMBA (7,12-Dimethylbenz(a)anthracene) is a potent c-Myc inducer known for its role as a carcinogen due to its polycyclic aromatic hydrocarbon structure. This compound is widely utilized in experimental research to induce tumor formation in rodent models, enabling the study of cancer biology, tumorigenesis, and potential therapeutic interventions. Its application is critical in understanding the mechanisms of cancer development and the role of oncogenes.