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Ras

Ras inhibitors and related small GTPase modulators act on KRAS and on the Rac, Rho and Cdc42 proteins. Small GTPases of the Ras superfamily work as molecular switches. They cycle between an active form bound to guanosine triphosphate (GTP) and an inactive form bound to guanosine diphosphate (GDP). Oncogenic KRAS mutations such as G12C keep the protein in its signaling state. ARS-853 and KRas G12C inhibitor 4 target the mutant cysteine of KRAS G12C, while Kobe2602 interferes with binding of Ras to Raf. Salirasib, a farnesylcysteine mimetic, disrupts the membrane association of Ras. Rho-family tools include NSC 23766 and EHT 1864, which inhibit Rac, and CASIN, which targets Cdc42.

Items 26-30 of 30

  • Sp-8-Br-2'-O-Me-cAMPS
    Cat. No.
    A63805
    CAS No.
    634208-34-7

    Sp-8-Br-2'-O-Me-cAMPS

    Sp-8-Br-2'-O-Me-cAMPS is a cAMP analog that serves as a potent activator of the exchange protein directly activated by cyclic AMP (EPAC). This compound is valuable for studying the role of EPAC in various biological pathways, particularly those related to metabolism. Its ability to modulate EPAC activity makes it an important tool for investigating signaling mechanisms and their implications in metabolic processes.

    In stock View Details
    25 mg
    $1,275.00
    50 mg
    $1,625.00
    All 3 sizes
  • NY-0173
    Cat. No.
    A63809
    CAS No.
    1801911-86-3

    NY-0173

    NY-0173 is an antagonist of exchange proteins directly activated by cAMP (EPAC), demonstrating IC50 values of 3.5 μM for EPAC2 and 4.0 μM for EPAC1. This reagent serves as a valuable tool for investigating the biological roles and pathways mediated by EPAC. Researchers can utilize NY-0173 to explore its impact on cellular processes influenced by EPAC signaling.

    In stock View Details
    25 mg
    $1,275.00
    50 mg
    $1,625.00
    All 3 sizes
  • Goralatide
    Cat. No.
    A63811
    CAS No.
    120081-14-3

    Goralatide

    Goralatide is a Ra activator that modulates the thermal sensitivity of hematopoietic progenitor cells. It enhances the disparity in thermal sensitivity between leukemia progenitor cells and normal hematopoietic progenitor cells, thereby increasing the efficacy of hyperthermia therapy. This compound is relevant for research in cancer treatment strategies, particularly those involving targeted thermal therapies.

    In stock View Details
    5 mg
    $360.00
    All 1 sizes
  • Sp-8-pCPT-2'-O-Me-cAMPS
    Cat. No.
    A63812
    CAS No.
    634208-37-0

    Sp-8-pCPT-2'-O-Me-cAMPS

    Sp-8-pCPT-2'-O-Me-cAMPS is a selective activator of the exchange protein directly activated by cyclic AMP (EPAC). This compound enhances EPAC-mediated signaling pathways, playing a significant role in the regulation of various physiological processes. It is valuable for research into endocrine metabolism and related signaling mechanisms.

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    Out of stock

    All 3 sizes
  • 2-AHA-cAMP
    Cat. No.
    B11165
    CAS No.
    214276-80-9

    2-AHA-cAMP

    2-AHA-cAMP is a cAMP analogue that acts as an activator of cAMP-dependent protein kinase. The molecule features a free terminal primary amino group, enabling its coupling to gels or fluorescent dyes for enhanced experimental versatility. Its application extends to various research areas including signaling pathways and protein interaction studies, making it a valuable reagent for biophysical and biochemical investigations.

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    Out of stock

    All 3 sizes

Items 26-30 of 30

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