Ras

Cat. No.

A15925

CAS No.

878978-76-8

ML-098

Synonyms: CID-7345532

ML-098 is an activator of the GTP-binding protein Rab7 (EC50 = 77.6 nM).

Cat. No.

A16231

CAS No.

2002381-25-9

APS-2-79

APS-2-79 is an antagonist of MEK phosphorylation by RAF through direct binding of the KSR active site.

Cat. No.

A20067

CAS No.

143703-25-7

CE3F4

CE3F4 is a selective antagonist of exchange protein directly activated by cAMP (Epac1), with IC50s of 10.7 μM and 66 μM for Epac1 and Epac2(B), respectively.

Cat. No.

A24225

CAS No.

496775-95-2

ML-099 (CID-888706)

Synonyms: CID-888706

ML-099 (CID-888706) is a pan Ras-related GTPase activator that promotes the activation of multiple small GTPases, including Rac1, Cdc42, Ras, Rab7, and Rab2A. It serves as a useful tool for studying the regulation and function of Ras-related GTPase signaling pathways.

Cat. No.

A24569

CAS No.

2245237-53-8

VUBI1 (SOS1 activator 1)

Synonyms: SOS1 activator 1

VUBI1 (SOS1 Activator 1) is a benzimidazole-derived small molecule that acts as a potent activator of the guanine nucleotide exchange factor SOS1, with a dissociation constant (Kᴅ) of 44 nM. It promotes RAS activation by enhancing RAS-GTP formation and modulates downstream ERK phosphorylation, thereby influencing RAS–MAPK signaling. In addition, VUBI1 serves as a functional ligand for the development of PROTAC-based degraders, such as PROTAC SOS1 Degrader-1, to induce targeted SOS1 degradation. VUBI1 is a valuable compound for studying RAS pathway regulation and its role in cancer biology.

Cat. No.

A24573

CAS No.

301177-43-5

ESI-08

ESI-08 is a potent and selective antagonist of exchange proteins directly activated by cAMP (EPACs). It inhibits both EPAC1 and EPAC2 with an IC₅₀ of 8.4 μM, effectively blocking cAMP-induced EPAC activation while sparing cAMP-mediated protein kinase A (PKA) signaling. By selectively disrupting EPAC-dependent pathways, ESI-08 serves as a valuable tool compound for dissecting cAMP signaling mechanisms and studying EPAC-related physiological and pathological processes.

Cat. No.

A24683

CAS No.

1383539-73-8

HJC0197

HJC0197 is a selective antagonist of Epac1 and Epac2, exhibiting an IC50 of 5.9 μM for Epac2. This compound effectively inhibits cAMP-induced activation of Epac, demonstrating a capacity to block Epac1-mediated Rap1-GDP exchange activity at a concentration of 25 μM in the presence of a corresponding concentration of cAMP. HJC0197 serves as a valuable tool for investigating the role of Epac proteins in cellular signaling pathways and cAMP-mediated biological processes.

Cat. No.

A24805

CAS No.

74805-91-7

Methylophiopogonanone B

Methylophiopogonanone B is a homoisoflavonoid that serves as a Ras activator. Isolated from the root of Ophiopogon japonicus, it exhibits potent antioxidant properties. This compound enhances GTP-Rho levels and activates the Rho signaling pathway, thereby inducing morphological changes in cells, such as actin cytoskeletal reorganization, dendrite retraction, and stress fiber formation. It is a valuable reagent for research into cellular signaling and structural dynamics.

Cat. No.

A24811

CAS No.

743456-83-9

ML-097

Synonyms: CID-2160985

ML-097 is a potent activator of Ras-related GTPases, specifically targeting Rac1, CDC42, Ras, and Rab7. It plays a critical role in modulating cellular signaling pathways associated with proliferation, migration, and cytoskeletal organization. This compound is valuable for research applications focusing on cancer biology, neurobiology, and cellular communication mechanisms.

Cat. No.

A24815

CAS No.

634207-53-7

8-pCPT-2′-O-Me-cAMP sodium

Synonyms: 8-CPT-2'-O-Me-cAMP sodium

8-pCPT-2′-O-Me-cAMP sodium is an analog of cyclic AMP that serves as a selective activator of exchange proteins activated by cAMP (Epac). This compound demonstrates effective activation of Epac1 with an EC50 value of 2.2 μM, while showing minimal activity towards protein kinase A (EC50 >10 μM). In vitro studies highlight its role in stimulating Epac-mediated Ca2+ release in pancreatic β-cells, and it functions as an activator of Rap1. Additionally, 8-pCPT-2′-O-Me-cAMP sodium has been shown to strengthen the barrier of retinal pigment epithelium against pathological choroidal endothelial cell invasion, contributing to research on macular degeneration.

Cat. No.

A37215

CAS No.

59212-44-1

8-HA-cAMP

Synonyms: 8-Hexylamino-cAMP

8-HA-cAMP is a membrane-permeable analogue of cyclic adenosine monophosphate (cAMP) that acts as an activator of cAMP-dependent protein kinase (PKA). Its structure confers metabolic stability against mammalian phosphodiesterases that respond to cyclic nucleotides. This compound is useful in studying PKA signaling pathways and their associated biological processes.

Cat. No.

A63619

CAS No.

663941-66-0

8-CPT-cAMP-AM

Synonyms: 8-(4-Chlorophenylthio)-cAMP-AM

8-CPT-cAMP-AM is a membrane-permeant analogue of cyclic adenosine monophosphate (cAMP) that acts as an activator of cAMP- and cGMP-dependent protein kinases. It also stimulates exchange protein directly activated by cAMP (Epac), making it a valuable tool for investigating cAMP signaling pathways. This compound is useful in research applications studying cellular processes influenced by cAMP, such as cell proliferation, differentiation, and effects on various physiological responses.

Cat. No.

A63650

CAS No.

1579978-17-8

RAS activator compound 1

RAS Activator Compound 1 is a specific activator targeting the guanine nucleotide exchange factor, son of sevenless homologue 1 (SOS1). This compound effectively facilitates the nucleotide exchange process, leading to increased levels of active RAS-GTP in HeLa cells. RAS Activator Compound 1 is valuable for research focused on RAS-driven tumors, providing insights into the mechanisms of RAS activation and its role in cancer biology.

Cat. No.

A63658

CAS No.

510774-50-2

8-pCPT-2′-O-Me-cAMP

Synonyms: 8-CPT-2'-O-Me-cAMP

8-pCPT-2′-O-Me-cAMP is a selective activator of exchange proteins activated by cAMP (Epac), specifically targeting Epac1 with an EC50 of 2.2 μM. This compound does not activate protein kinase A (PKA) with an EC50 greater than 10 μM. 8-pCPT-2′-O-Me-cAMP effectively stimulates Epac-mediated Ca2+ release in pancreatic β-cells in vitro, and it plays a role as a Rap1 activator. Additionally, it enhances the barrier function of retinal pigment epithelium against choroidal endothelial cell invasion, potentially providing insights into therapeutic mechanisms for macular degeneration.

Cat. No.

A63669

CAS No.

905794-70-9

K-Ras-IN-2

K-Ras-IN-2 is a selective antagonist of the K-Ras protein. It has demonstrated significant biological activity in inhibiting K-Ras-driven signaling pathways, making it a valuable tool for researchers studying tumor biology and oncogenic signaling. This compound is particularly useful in cancer research applications focused on K-Ras-related malignancies.

Cat. No.

A63722

CAS No.

2928616-74-2

JH530

JH530 is a potent inducer of methuosis, specifically targeting triple-negative breast cancer (TNBC) cells. It triggers extensive intracellular vacuolization, leading to the inhibition of TNBC cell proliferation. With its demonstrated anti-tumor activity, JH530 serves as a valuable tool for cancer research applications.

Cat. No.

A63805

CAS No.

634208-34-7

Sp-8-Br-2'-O-Me-cAMPS

Sp-8-Br-2'-O-Me-cAMPS is a cAMP analog that serves as a potent activator of the exchange protein directly activated by cyclic AMP (EPAC). This compound is valuable for studying the role of EPAC in various biological pathways, particularly those related to metabolism. Its ability to modulate EPAC activity makes it an important tool for investigating signaling mechanisms and their implications in metabolic processes.

Cat. No.

A63809

CAS No.

1801911-86-3

NY-0173

NY-0173 is an antagonist of exchange proteins directly activated by cAMP (EPAC), demonstrating IC50 values of 3.5 μM for EPAC2 and 4.0 μM for EPAC1. This reagent serves as a valuable tool for investigating the biological roles and pathways mediated by EPAC. Researchers can utilize NY-0173 to explore its impact on cellular processes influenced by EPAC signaling.

Cat. No.

A63811

CAS No.

120081-14-3

Goralatide

Goralatide is a Ra activator that modulates the thermal sensitivity of hematopoietic progenitor cells. It enhances the disparity in thermal sensitivity between leukemia progenitor cells and normal hematopoietic progenitor cells, thereby increasing the efficacy of hyperthermia therapy. This compound is relevant for research in cancer treatment strategies, particularly those involving targeted thermal therapies.

Cat. No.

A63812

CAS No.

634208-37-0

Sp-8-pCPT-2'-O-Me-cAMPS

Sp-8-pCPT-2'-O-Me-cAMPS is a selective activator of the exchange protein directly activated by cyclic AMP (EPAC). This compound enhances EPAC-mediated signaling pathways, playing a significant role in the regulation of various physiological processes. It is valuable for research into endocrine metabolism and related signaling mechanisms.

Cat. No.

B11165

CAS No.

214276-80-9

2-AHA-cAMP

2-AHA-cAMP is a cAMP analogue that acts as an activator of cAMP-dependent protein kinase. The molecule features a free terminal primary amino group, enabling its coupling to gels or fluorescent dyes for enhanced experimental versatility. Its application extends to various research areas including signaling pathways and protein interaction studies, making it a valuable reagent for biophysical and biochemical investigations.