Fig. 1 · Structure
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OB-24 free base
Cat. No.
B18745
CAS
940061-39-2
HO-1 Inhibitor
OB-24 free base is a selective inhibitor of heme oxygenase 1 (HO-1), demonstrating notable potential for targeting advanced prostate cancer. This compound effectively reduces protein carbonylation and diminishes the formation of reactive oxygen species in prostate cancer cells through its specific inhibition of HO-1 activity. In vitro studies reveal that OB-24 significantly impairs cell proliferation, while in vivo experiments show a marked reduction in tumor growth and metastasis to lymph nodes and lungs. Additionally, OB-24 displays enhanced efficacy when used in conjunction with Taxol, making it a valuable tool for cancer research.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 940061-39-2 |
| Applications | HO-1 Inhibitor |
| Formula | C15H17BrN2O2 |
| Molecular Weight | 337.21 |
| SMILES | BrC1=CC=C(CCC2(CN3C=NC=C3)OCCO2)C=C1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.