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Adenosine triphosphate-citrate lyase (ACLY) links cellular carbon metabolism with lipid synthesis. The enzyme supplies cytosolic acetyl groups that contribute to biosynthesis and protein acetylation, connecting nutrient metabolism with gene regulation. This category includes BMS303141, SB 204990 and NDI-091143, each annotated as an ACLY inhibitor. These compounds represent different chemical approaches to studying the same enzyme. The selection is relevant to investigations of metabolic flux, lipid-associated pathways and the relationship between intermediary metabolism and chromatin regulation.
