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AhR

Aryl hydrocarbon receptor (AhR) ligands act on a ligand-activated transcription factor of the bHLH-PAS family. Cloning of the receptor complementary DNA in 1992 showed that AhR combines a basic helix-loop-helix (bHLH) domain with a Per-Arnt-Sim (PAS) domain. The tryptophan metabolite kynurenine was later described as an endogenous agonist produced by tryptophan 2,3-dioxygenase. Antagonists of AhR were shown to support the expansion of human hematopoietic stem cells in culture, which made StemRegenin 1 a common tool in that work. CH-223191, ITE, tapinarof and L-Kynurenine complete a set that covers both receptor activation and blockade in reporter and gene expression assays.

3 Items

  • SGA360
    Cat. No.
    A22106
    CAS No.
    680611-86-3

    SGA360

    SGA360 is a selective modulator of aryl hydrocarbon (Ah) receptor that exhibits anti-inflammatory properties.

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    1 mg
    $30.00
    5 mg
    $110.00
    All 8 sizes
  • AhR modulator-1
    Cat. No.
    A34801
    CAS No.
    118174-38-2

    AhR modulator-1

    AhR Modulator-1 (6-MCDF) is a selective and orally active modulator of the aryl hydrocarbon receptor (AhR). This compound demonstrates significant inhibition of metastasis by reducing vascular endothelial growth factor (VEGF) production in prostatic tissues prior to tumor formation. Additionally, AhR Modulator-1 exhibits anti-estrogenic effects in the rat uterus, making it a valuable tool for investigating the roles of AhR in cancer biology and endocrine regulation.

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    Out of stock

    All 3 sizes
  • DiMNF
    Cat. No.
    A64091
    CAS No.
    14756-24-2

    DiMNF

    Synonyms: 3',4'-Dimethoxy-αNF

    DiMNF (3',4'-Dimethoxy-αNF) is a selective modulator of the aryl hydrocarbon receptor (AHR). Acting as a competitive ligand with an IC50 of 21 nM, it exhibits antagonistic properties that can be harnessed in anti-inflammatory research. DiMNF is valuable for investigating the role of AHR in various biological processes and potential therapeutic applications.

    In stock View Details
    1 mg
    $30.00
    5 mg
    $70.00
    All 7 sizes

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