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FAAH

FAAH inhibitors act on fatty acid amide hydrolase (FAAH), a serine hydrolase that ends anandamide signaling. The enzyme was cloned in 1996 as a membrane protein that hydrolyzes oleamide, anandamide and related fatty acid amides. Inhibiting FAAH raises endogenous anandamide levels without directly binding cannabinoid receptors. In 2003, URB597 increased brain anandamide and produced anxiolytic-like effects in rats. PF-3845 and PF-04457845 are covalent FAAH inhibitors, and JNJ-42165279 and BIA 10-2474 extend the set. JZL195 inhibits both FAAH and monoacylglycerol lipase (MAGL) and also appears under Lipase. FP-Biotin is a biotinylated fluorophosphonate probe for activity-based profiling of serine hydrolases.

1 Item

  • CB2R/FAAH modulator-2
    Cat. No.
    A59304
    CAS No.
    2876918-68-0

    CB2R/FAAH modulator-2

    CB2R/FAAH modulator-2 is a dual-targeting modulator that functions as an agonist of the cannabinoid receptor 2 (CB2R) and an inhibitor of fatty acid amide hydrolase (FAAH). It exhibits Ki values of 10.8 nM for CB2R and 152.9 nM for CB1R, with an IC50 of 6.2 μM for FAAH. This compound is suitable for investigating therapeutic applications in cancer, neurodegenerative diseases characterized by inflammatory processes, and potential impacts on COVID-19 infection pathways.

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    1 mg
    $25.00
    5 mg
    $60.00
    All 6 sizes

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