FXR | Adooq Bioscience

Cat. No.: A69104

CAS No.: 3067566-36-0

FXR/HSD17B13 modulator 1

FXR/HSD17B13 modulator 1 is a potent modulator targeting the farnesoid X receptor (FXR) and hydroxysteroid dehydrogenase 17 beta 13 (HSD17B13). This compound demonstrates significant biological activity relevant to the study of metabolic dysfunction-associated steatohepatitis (MASH). Its modulation of these targets can provide insights into therapeutic strategies for liver-related metabolic disorders.

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Cat. No.: A70457

CAS No.: 570-63-8

3-Epideoxycholic acid

3-Epideoxycholic acid is a modulator of the Farnesoid X receptor (FXR), primarily influencing dendritic cell function. This compound reduces the immunostimulatory capacity of dendritic cells, facilitating the generation of regulatory T cells (Tregs) and exhibiting notable anti-inflammatory effects. Additionally, 3-Epideoxycholic acid promotes the growth of beneficial gut bacteria, specifically Bacteroides, making it relevant for research in immunology and microbiome studies.

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Cat. No.: A74872

CAS No.: 58814-71-4

Chenodeoxycholic acid 3-glucuronide

Chenodeoxycholic acid 3-glucuronide is an active metabolite of Chenodeoxycholic acid that serves as a selective Farnesoid X receptor (FXR) activator, exhibiting an EC50 of 8 μM in in vitro assays. This compound effectively modulates FXR signaling pathways, which are crucial for bile acid homeostasis and lipid metabolism. Research applications include studying metabolic disorders, liver physiology, and the potential therapeutic effects of FXR activation in various disease models.

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Cat. No.: A74876

CAS No.: 3004676-77-8

ZLY28

ZLY28 is a first-in-class dual modulator targeting farnesoid X receptor (FXR) and fatty acid-binding protein 1 (FABP1). This orally active compound exhibits significant potential as an anti-NASH agent, making it a valuable tool for research into nonalcoholic steatohepatitis (NASH) and related metabolic conditions. Its intestinal-restricted activity highlights its specificity, providing an innovative approach to studying lipid metabolism and liver function.

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5 mg

$245.00

10 mg

$405.00

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Cat. No.: A74905

CAS No.: 3004676-87-0

FXR/CES2 modulator 1

FXR/CES2 modulator 1 is a dual modulator that functions as an FXR agonist and a CES2 inhibitor. This compound demonstrates significant potential in reducing the intestinal toxicity associated with irinotecan administration. Its unique mechanism of action makes it a valuable tool for research aimed at understanding FXR modulation and its implications in gastrointestinal safety during chemotherapy.

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Cat. No.: A74907

CAS No.: 2409154-23-8

BAR-2227

BAR-2227 is a modulator that targets the Farnesoid X Receptor (FXR) as an agonist and inhibits the leukemia inhibitory factor receptor (LIFR). This compound plays a significant role in the investigation of liver fibrosis and associated inflammatory responses. Researchers can utilize BAR-2227 to explore its therapeutic potential in liver diseases and further elucidate underlying mechanisms of fibrosis and inflammation.

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Cat. No.: A74916

CAS No.: 80373-86-0

5β-Cholane

5β-Cholane is a potent activator of the farnesoid X receptor (FXR). It plays a critical role in regulating bile acid homeostasis and lipid metabolism, making it a valuable tool for investigating cholesterol and lipid-related disorders. Researchers can utilize 5β-Cholane to better understand the molecular mechanisms underlying metabolic diseases and to explore therapeutic interventions targeting FXR.

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Cat. No.: A74919

CAS No.: 2982502-32-7

FXR agonist 9

FXR agonist 9 is a selective partial agonist of the farnesoid X receptor (FXR) with an EC50 of 0.09 µM, exhibiting 75.13% maximum efficacy. This compound has demonstrated the ability to improve pathological features associated with metabolic dysfunction and steatohepatitis in mouse models induced by a high-fat diet and carbon tetrachloride. FXR agonist 9 is valuable for research into metabolic disorders and liver diseases.

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