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GLUT inhibitors and modulators act on glucose transporters, the membrane carriers that move glucose into cells. The glucose transporter (GLUT) proteins belong to the solute carrier family 2 (SLC2) and mediate facilitated diffusion of hexoses. GLUT1 was the first member to be sequenced, in 1985, and its crystal structure was reported in 2014. Because many tumor cells rely on increased glucose uptake, GLUT1 is a frequent subject of cancer metabolism research. BAY-876 was described as a highly selective GLUT1 inhibitor, and WZB117 and STF-31 also target GLUT1. Glutor acts on several isoforms, while D927 promotes GLUT4 translocation for studies of insulin-regulated glucose uptake.
Synonyms: GLUT4 activator 1; DS11252927
D927 (GLUT4 activator 1, DS11252927) is a potent glucose transporter type 4 (GLUT4) translocation activator with an EC50 of 0.14 μM.
DS-1150b is a potent GLUT4 activator that effectively enhances glucose transport in skeletal muscle cells by promoting the translocation of GLUT4 to the cell membrane. This compound has demonstrated hypoglycemic effects in the Zucker obese rat model, making it a valuable tool for research into type 2 diabetes mellitus (T2DM). Its oral bioavailability further supports its utility in metabolic studies and therapeutic development aimed at improving glucose homeostasis.
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