Phospholipases

Cat. No.

A77204

CAS No.

245126-95-8

Phosphatidylinositol 4,5-bisphosphate

Synonyms: L-alpha-Phosphatidylinositol-4,5-bisphosphate; (PtdIns)-(4,5)-P2

Phosphatidylinositol 4,5-bisphosphate serves as a critical substrate for phospholipase C, facilitating the production of diacylglycerol and inositol (1,4,5)-trisphosphate. This phospholipid is predominantly located in the cytoplasmic leaflet of the plasma membrane and plays a pivotal role in cellular processes such as lamellipodial protrusion, directional cell migration, and focal adhesion formation. Additionally, it is involved in the trafficking of GABAA receptors. Phosphatidylinositol 4,5-bisphosphate is relevant for research focusing on acute lung injury and pulmonary edema.

Cat. No.

A77222

CAS No.

1902292-78-7

DPPI-4,5-P2 ammonium

DPPI-4,5-P2 ammonium is a substrate for Phosphoinositide-specific phospholipase C-δ1 (PI-PLC-δ1), an enzyme critical in phosphoinositide signaling pathways. This compound is essential for studying the catalytic activity of PI-PLC-δ1 and its role in various cellular processes, including signal transduction and membrane remodeling. It serves as a valuable tool in biochemical assays and research focused on phosphoinositide metabolism.