Fig. 1 · Structure
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Cemtirestat
ALR2 Inhibitor
Cemtirestat is a carboxymethylated thiatriazinoindole that functions as an inhibitor of aldose reductase (ALR2). It demonstrates potent inhibition of rat ocular lens ALR2, with an IC50 of 0.116 μM, and displays a significant 302-fold selectivity for rat kidney ALR1. This compound is primarily utilized in research focused on advanced diabetic complications.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 309283-89-4 |
| Applications | ALR2 Inhibitor |
| Formula | C11H8N4O2S |
| Molecular Weight | 260.27 |
| Synonyms | CMTI |
| SMILES | O=C(O)CN1C=2C=CC=CC2C=3N=NC(=S)NC31 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.