Fig. 1 · Structure
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CGP-49823
NK1 Receptor Antagoinst
CGP-49823 is a selective antagonist of the neurokinin 1 receptor (NK1 receptor) with oral bioavailability. It exhibits potent anti-anxiety effects, demonstrated in social interaction assays in rats, and shows a slow development of tolerance without eliciting anxiety-like withdrawal symptoms upon cessation. This compound is applicable in research focused on anxiety and depression.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 150705-88-7 |
| Applications | NK1 Receptor Antagoinst |
| Formula | C31H33N3O |
| Molecular Weight | 463.61 |
| SMILES | O=C(N1[C@H](CC2=CC=CC=C2)C[C@@H](NCC3=CC=NC4=CC=CC=C34)CC1)C5=CC(C)=CC(C)=C5 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.