Fig. 1 · Structure
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CGS 27023A free base
MMP Inhibitor
CGS 27023A free base is a potent, non-peptidic inhibitor of matrix metalloproteinases (MMPs), demonstrating Ki values of 43 nM for MMP-3, 33 nM for MMP-1, 20 nM for MMP-2, and 8 nM for MMP-9. This compound effectively inhibits cartilage degradation in a stromelysin-induced rabbit model, making it a valuable tool for studying the pathogenesis of arthritis and potential therapeutic interventions. Its selective inhibition of MMPs underscores its relevance in research focused on inflammatory and degenerative joint diseases.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 161314-70-1 |
| Applications | MMP Inhibitor |
| Formula | C18H23N3O5S |
| Molecular Weight | 393.46 |
| SMILES | CC(C)[C@@H](N(S(=O)(C1=CC=C(OC)C=C1)=O)CC2=CC=CN=C2)C(NO)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.