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CH5447240

PTHR Agonist

CH5447240 is a potent agonist of parathyroid hormone receptor 1 (PTHR1), demonstrating an EC50 of 12 μM in human PTHR1 inhibition. It shows favorable metabolic stability in human liver microsomes and effectively elevates serum calcium levels in rodent models. This compound is valuable for research investigating hypoparathyroidism and related disorders.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Agonist
CAS Number	1253919-92-4
Applications	PTHR Agonist
Formula	C₂₆H₃₉N₅O₄S
Molecular Weight	517.68
SMILES	O=C(N)N(C1=CC(C)=C(CCS(=O)(N(CC2)CCC2(NC([C@H]3CC[C@H](C)CC3)=N4)C4=O)=O)C(C)=C1)C

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.