Parathyroid Hormone Receptor (PTH1R)

Cat. No.

A14896

CAS No.

12583-68-5

Parathyroid Hormone (1-34), bovine

Parathyroid hormone (PTH) is the most important endocrine regulator of calcium and phosphorus concentration in extracellular fluid, which is secreted by the chief cell of the parathyroid glands as a polypeptide containing 84 amino acids.

Cat. No.

A12790

CAS No.

52232-67-4

Parathyroid Hormone 1-34, Human

Synonyms: Teriparatide acetate

Human parathyroid hormone (hPTH) peptide fragment; contains the 34 N-terminal residues of hPTH. Agonist at parathyroid 1 (PTH1) and parathyroid 2 (PTH2) receptors.

Cat. No.

A30852

CAS No.

90880-43-6

pTH (39-84) (human)

pTH (39-84) (human) is a C-terminal fragment of parathyroid hormone that primarily targets the regulation of bone metabolism. This fragment has been shown to increase apoptosis in various cellular contexts and stimulates the formation of osteoclasts, playing a crucial role in bone resorption. It is employed in research applications investigating bone remodeling and the mechanisms underlying osteoporosis and related bone disorders.

Cat. No.

A46206

CAS No.

120298-73-9

pTH-Related Protein (1-40) (human, mouse, rat)

pTH-Related Protein (1-40) is an activator of the parathyroid hormone receptor (PTHR) and protein kinase C isoforms α and β. This peptide enhances calcium uptake in rat intestinal cells by stimulating the PTHR1 receptor, leading to the upregulation of critical calcium transport proteins, including TRPV6, CaBP-D9k, NCX1, and PMCA1. Its biological activity makes it a valuable tool for research focused on calcium signaling and endocrine regulation in both human and animal models.

Cat. No.

A63509

CAS No.

172867-62-8

Human PTHrP-(1-36)

Human PTHrP-(1-36) is a skeletal anabolic agent that primarily targets the parathyroid hormone-related peptide receptor. This compound exhibits anticalciuric effects and promotes beta cell function and proliferation. It is relevant for research into humoral hypercalcemia of malignancy (HHM) and hyperparathyroidism, providing insights into calcium homeostasis and metabolic regulation.

Cat. No.

A63510

CAS No.

3106850-44-3

PTH1R agonist 2

PTH1R agonist 2 is a selective agonist of the parathyroid hormone 1 receptor (PTH1R). This compound demonstrates significant biological activity in promoting osteoblastic activity and calcium homeostasis, making it valuable for studies related to hypoparathyroidism and osteoporosis. Its potential applications span the investigation of bone metabolism and therapeutic strategies for metabolic bone diseases.

Cat. No.

A63515

CAS No.

120527-89-1

[Nle8,18,Tyr34]-pTH (3-34) amide (human)

Synonyms: [Nle8'18,Tyr34]hPTH (3-34) amide

[Nle8,18,Tyr34]-pTH (3-34) amide (human) is a synthetic analog of parathyroid hormone (PTH), specifically designed to target the PTH receptor. This compound exhibits significant biological activity related to calcium homeostasis and bone metabolism, making it valuable for research in osteoporosis and related disorders. Its application extends to studies investigating the mechanisms of PTH signaling and the development of therapeutic strategies targeting bone density and mineral balance.

Cat. No.

A63516

CAS No.

99294-94-7

Teriparatide acetate hydrate

Synonyms: Human parathyroid hormone-(1-34) acetate hydrate; hPTH (1-34) acetate hydrate

Teriparatide acetate hydrate is a parathyroid hormone (PTH) receptor agonist, specifically acting on the PTH1 receptor. This compound exhibits key biological activity by stimulating bone formation and enhancing calcium absorption, making it crucial for osteoporosis research. Its application extends to studying osteoporosis and related bone metabolism disorders, facilitating the development of therapeutic strategies for bone health.

Cat. No.

A63517

CAS No.

3106336-35-7

PTH1R agonist 1

PTH1R Agonist 1 is a specialized agonist of the parathyroid hormone 1 receptor (PTH1R). This compound exhibits key biological activity by stimulating PTH1R signaling pathways, making it a valuable tool for investigating conditions related to hypoparathyroidism and osteoporosis. Its relevance in research encompasses the exploration of therapeutic strategies targeting bone metabolism and calcium homeostasis.

Cat. No.

A63521

CAS No.

1253919-92-4

CH5447240

CH5447240 is a potent agonist of parathyroid hormone receptor 1 (PTHR1), demonstrating an EC50 of 12 μM in human PTHR1 inhibition. It shows favorable metabolic stability in human liver microsomes and effectively elevates serum calcium levels in rodent models. This compound is valuable for research investigating hypoparathyroidism and related disorders.

Cat. No.

A63523

CAS No.

1413439-62-9

Octadecyl β-D-glucopyranosiduronic acid

Octadecyl β-D-glucopyranosiduronic acid is an activator of the parathyroid hormone 1 receptor (PTH1R), exhibiting a pEC50 value greater than 9. This compound plays a significant role in advancing research in hypoparathyroidism, facilitating studies aimed at understanding receptor activation and its physiological implications. Its ability to modulate PTH1R signaling can provide critical insights into therapeutic approaches for disorders related to calcium homeostasis.

Cat. No.

A63524

CAS No.

3106619-54-6

PTH1R agonist 4

PTH1R Agonist 4 is a selective agonist of the parathyroid hormone 1 receptor (PTH1R), exhibiting a pEC50 value exceeding 7. This compound is valuable for investigating bone metabolic processes and holds potential applications in the study of bone diseases, including osteoporosis. Its ability to activate PTH1R makes it a significant tool for research in therapeutic strategies targeting bone health.

Cat. No.

A85439

CAS No.

98614-76-7

Parathyroid hormone (1-34) (rat)

Parathyroid hormone (1-34) (rat) is a peptide hormone that primarily targets bone metabolism through the activation of parathyroid hormone receptors. This compound is known to enhance both cortical and cancellous bone structure, making it a valuable tool in the study of osteogenesis and bone remodeling. It is particularly useful in research focused on osteoporosis and related bone disorders.

Cat. No.

A85459

CAS No.

64421-69-8

pTH (44-68) (human)

pTH (44-68) (human) is a fragment of the human parathyroid hormone. This peptide plays a crucial role in regulating calcium homeostasis and bone metabolism by acting on the parathyroid hormone receptors. pTH (44-68) is primarily used in research applications focused on osteoporosis, metabolic bone disease, and calcium signaling pathways. Its specific activity allows for the investigation of parathyroid hormone signaling mechanisms and potential therapeutic interventions.

Cat. No.

A85466

CAS No.

85568-24-7

pTH (1-44) (human)

pTH (1-44) (human) is a truncated form of human parathyroid hormone, encompassing amino acids 1 to 44. This fragment primarily targets the parathyroid hormone receptor, playing a crucial role in calcium homeostasis and bone metabolism. It is widely used in research applications focused on bone density studies, calcium signaling pathways, and the pathophysiology of metabolic bone diseases.

Cat. No.

A85472

CAS No.

81306-64-1

pTH (13-34) (human)

pTH (13-34) (human) is a fragment of the human parathyroid hormone that primarily targets parathyroid hormone receptors. This peptide is known to regulate calcium and phosphate homeostasis by stimulating osteoclast activity and increasing renal tubular reabsorption of calcium. It is commonly used in research to study bone metabolism, calcium signaling, and related endocrine disorders.

Cat. No.

A85482

CAS No.

89439-30-5

pTH (53-84) (human)

pTH (53-84) (human) is a fragment of human parathyroid hormone, primarily functioning to regulate calcium homeostasis and bone metabolism. This peptide plays a critical role in stimulating osteoclast activity and enhancing renal tubular reabsorption of calcium. It is widely utilized in research related to bone diseases, calcium signaling, and metabolic disorders associated with parathyroid function.

Cat. No.

A85487

CAS No.

51257-86-4

pTH (3-34) (bovine)

pTH (3-34) (bovine) is a fragment of the human parathyroid hormone (PTH) that primarily targets the parathyroid hormone receptor. This peptide plays a crucial role in the regulation of calcium homeostasis and bone metabolism. It is commonly used in research applications related to bone health, osteoporosis studies, and the investigation of mineral ion balance.

Cat. No.

AP3315

PTHrP Human

Parathyroid Hormone Related Protein Human Recombinant

Cat. No.

AP3316

PTHrP N15 Human

Parathyroid Hormone Related Protein N15 Labeled Human Recombinant

Cat. No.

AP3319

PTH (1-34) Human Recombinant

Parathyroid Hormone (1-34) Human Recombinant

Cat. No.

AP3322

PTH (1-34) Human

Parathyroid Hormone (1-34) Human